Estrogen Replacement Reduces Age-Associated Remodeling in Rat Mesenteric Arteries
نویسندگان
چکیده
منابع مشابه
Estrogen replacement reduces age-associated remodeling in rat mesenteric arteries.
Estrogen replacement therapy significantly decreases the incidence of cardiovascular disease in postmenopausal women. In aging, there is an increase in vascular stiffness along with a decrease in matrix metalloproteinase (MMP) activity. Our hypothesis was that estrogen replacement would increase MMPs and therefore reduce the vascular stiffness that is associated with aging. Female Sprague-Dawle...
متن کاملEffect of estrogen replacement on vasoconstrictor responses in rat mesenteric arteries.
Recent studies have shown that estrogen can increase endothelial nitric oxide synthase expression and/or activity and that nitric oxide may play a role in attenuating vasoconstrictor responses. Yet there are still controversies in this field. Our hypothesis was that the role of nitric oxide in modulating vasoconstrictor responses in estrogen-replaced animals depends on the agonist. The aim of t...
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There is evidence that estrogen can upregulate nitric oxide (NO) synthase expression. There is also evidence that NO increases the activity of prostaglandin H synthase (PGHS). Our initial hypothesis was that removal of ovarian steroids would decrease endothelium/NO-dependent relaxation responses but that estrogen replacement would increase NO and PGHS activity, leading to increased vasodilation...
متن کاملRole of estrogens and age in flow-mediated outward remodeling of rat mesenteric resistance arteries.
In resistance arteries, a chronic increase in blood flow induces hypertrophic outward remodeling. This flow-mediated remodeling (FMR) is absent in male rats aged 10 mo and more. As FMR depends on estrogens in 3-mo-old female rats, we hypothesized that it might be preserved in 12-mo-old female rats. Blood flow was increased in vivo in mesenteric resistance arteries after ligation of the side art...
متن کاملAge-associated endothelial dysfunction in rat mesenteric arteries: roles of calcium-activated K(+) channels (K(ca)).
Age-associated changes in large blood vessels were characterized by increased arterial wall thickness, luminal dilation and impaired endothelial function. But little is known about the effect of age on structural and functional changes in small resistance arteries. The mechanisms underlying age-associated endothelial dysfunction in rat mesenteric resistance arteries were investigated in the pre...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2000
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.36.6.970